Scientific strategy 

  • Re-search clinical diseases/syndromes in the context of modern genetics, biomarkers and disease course (given from electronic patient records)
  • Re-define previous diseases/syndromes into groups characterized by common genetic, immunological and clinical features
  • Re-design appropriate animal models that, when possible, mimic the mechanistically defined disease subsets.
  • Analyze etiology, molecular pathogenesis and targeted therapies in the context of new definitions of diseases and their models