WP6 - Chronic inflammatory disease and cardiovascular co-morbidities


 

WP coordinator: Solbritt Rantapää-Dahlqvist

Increased cardiovascular co-morbidity and mortality has been demonstrated in epidemiological studies in several of the chronic inflammatory diseases. A premature development of atherosclerosis has been shown and furthermore atherosclerosis per se can be regarded as an inflammatory disease by itself.

Within COMBINE we have the opportunity to gain knowledge about the interplay of genetic, environmental and immunological factors by using experimental animal models contributing to premature atherosclerosis and subsequent cardio vascular disease. This knowledge can de translated to comparative genetics and comparative pathway analyses within our large cohorts of patients with chronic inflammatory diseases. Etiopatogenetic mechanisms can be analysed by the use of animal models.

In the epidemiological studies by Solbritt Rantapää Dahlqvists group they found that patients with reumatoid arthritis (RA) from northern Sweden had, overall, an increased mortality due to cardiovascular disease, and more specifically ischaemic heart disease compared with the general population. Patients with RA had increased incidence of myocardial infarction compared with population controls from Västerbotten. The patients with RA had also significantly worse prognosis after the myocardial infarction.